Sr. Scientist

Description

Rangam is seeking candidates for a Contract role as a Sr. Scientist  with our client Pfizer, one of the world’s largest pharmaceutical companies. Seeking candidates in Bothell, WA or willing to relocate.

Position summary:

• We are looking for an energetic and experienced mass spectrometry scientist to join our Research ADC Characterization team in the Protein Solutions and Bioanalytical department.
• This individual will help us grow our mass spectrometry capabilities, lead the development of new or improved techniques for the characterization of proteins and antibody drug conjugates in various matrices, as well as maintain our shared mass spectrometers.
• They will also participate in collaborative, cross-functional teams to enable cancer therapeutic development and aid in exploring scientific questions surrounding antibody-based therapeutic activity and behavior.

Position responsibilities:

• Determine and develop novel and appropriate LC-MS methods for the characterization of intact ADCs, antibodies, and other proteins
• Develop and optimize both broadly applicable and fit-for-purpose methodologies for the capture, characterization, and quantification of proteins and conjugates from biological samples
• Perform peptide mapping to deeply characterize proteins and bioconjugates
• Provide care, maintenance, and troubleshooting of shared LC-MS instrumentation, including training new users and developing and maintaining best practices
• Provide technical and scientific advice and support to scientists of all levels, advise on LC and mass spectrometry related questions, and provide sample processing and data analysis for non-MS users
• Practice continuous improvement to refine methods and optimize processes, staying in touch with relevant literature and state of the art technologies
• Maintain strong communication and collaborative relationships with mass spectrometry groups outside of Research
• Create and organize technical information to deliver effective presentations in multiple forums

Organizational relationships:

• Working primarily with Protein BioAnlaytical Solutions (PBS) Conjugation group and Antibody Design and Engineering (AD&E) groups with some interactions with the Chemistry group.

Education and experience:

• A Ph.D. or equivalent experience in bioanalytical chemistry, analytical chemistry, pharmaceutical sciences, or a related discipline with recognized and established expertise in mass spectrometry
• 4+ years of research experience in the biotech/pharmaceutical industry or closely related academic areas
• Demonstrated experience in the operation and maintenance of mass spectrometers, their software, and applicable data analysis software
• Established capability in biological characterization and data analysis, specifically utilizing mass spectrometry techniques
• Attention to detail and a strong analytical mindset capable of proposing sound experimental strategies and developing new LC-MS protocols
• Uses critical thinking to solve complex problems, address challenges, overcome obstacles, and anticipate areas for growth
• Established safe laboratory skills and accurate record keeping
• Ability to work independently on routine experiments

Technical skills requirements:

Preferred qualifications include:

• Hands-on experience working with a Waters Xevo G2S QTof, Thermofisher Q Exactive, and/or SCIEX X500B QTOF
• Familiarity with affinity purification of proteins, peptides and/or metabolites.
• Experience analyzing all types of recombinant proteins
• Experience identifying and characterizing post-translational modifications or enzymatic modifications of proteins
• Experience with protein conformational analysis, such as Hydrogen deuterium exchange mass spectrometry
• Familiarity with Protein Metrics software and reporting, including high throughput data processing
• Experience or familiarity with mass spectrometry automation
• Knowledge of SEC-MALS biological analysis methods

Physical position requirements:

• Cytotoxic small molecules that are alone or attached to antibodies
• Organic solvents
• Rodent plasma

Hard Skills:

• LCMS
• Large molecule
• Anitbody exp.

Nice to Have

• ABC's
• Zenotof 7600
• Organized/Detailed Oriented/Team Player/Flexible

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.  These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

It is the policy of Rangam Consultants, Inc. to provide equal employment opportunities to all applicants and employees without regard to any legally protected status such as race, color, religion, gender, national origin, age, disability or veteran status. 

To find out more about Rangam, and this role, click the apply button.