Description

Gene Therapy Structural Biologist [Contractor]

This is a 1-year contract position, with the possibility to extend. This position is full-time on-site based in Waltham, MA.

Open to candidates willing to relocate at own expense Free Parking onsite Possibility of an extension No post-doctoral experience necessary

Must have :

• PhD Degree: Structural Biology, Biophysics, Molecular biology, biophysics, structural biology related degree
• Must have experience: cryo-EM, X-ray crystallography
• AAV Capsid, protein engineering
• Structuralizing and capsids

Nice to Have Skills:

• Previous immunology experience
• Biotech or pharma experience

Position Overview

• We are seeking a highly skilled and motivated Structural Biologist to join our team.
• This role will focus on elucidating the structural characteristics of AAV capsids to advance our gene therapy programs.

Key Responsibilities

• Design and execute structural biology experiments to characterize AAV capsid proteins
• Utilize cryo-EM and other biophysical techniques to determine AAV capsid structures
• Analyze structure-function relationships to guide rational design of novel AAV vectors
• Collaborate with gene therapy and protein engineering teams to develop improved AAV vectors
• Present findings to internal teams and at scientific conferences
• Publish research in peer-reviewed journals

Qualifications

• PhD (or equivalent) in Structural Biology, Biophysics, or closely related field; no post-doctoral experience necessary
• Necessary expertise in cryo-EM, X-ray crystallography, or related structural biology techniques
• Preferred (but not essential) experience with structural characterization of viral capsids, preferably AAV
• Strong background in protein biochemistry and molecular biology
• Experience with structure-based protein engineering is highly desirable
• Excellent analytical, problem-solving, and communication skills
• Candidates must be authorized to work in the United States

Preferred Skills

• Experience with computational modeling of protein structures
• Knowledge of gene therapy applications and vector development
• Familiarity with high-throughput screening approaches
• Track record of publications in structural biology or related fields