Description

Biologics Developability Screening and Automation

Open for candidates who are ready to relocate at their own expense

PhD with 1-2 yrs exp

Onsite role 100%

Early development science team

• GCMS deals with small molecules so will not work
• Academic and research exp will be considered
• Hamilton is used by client
• Bachelors or master’s degree needed or fresh PhD
• Protein based exp needed
• Protein mass spectrometry exp
• Mass spectrometry based
• Gene therapy and ADC
• Large molecules biologics
• Proteins or Biologics exp needed
• Experience with biochemical and biophysical characterization of biologic proteins would be preferred.
• Exp in sample prep and running samples in mass spectrometry
• Exp in biophysical techniques like chromatography
• Experience with liquid handling robots and their programming would be highly beneficial. (Nice to have)
• Industry exp will be given first preference
• Will be working cross functionally with pre-formulation team
• HPLC-MS or LCMS exp needed (Need biologics)

Summary

• The Biologics CMC Developability team is an integral part of the Biologics CMC Drug Product Development Org. The Biologics CMC Developability team is responsible for-
• the identification of biophysical- and chemical liabilities in discovery-stage biologic drug candidates to guide lead selection,
• for characterization of the key CMC attributes important for biologic drug development. We have an exciting opportunity for a motivated scientist to join the Biologics CMC Developability team.

Key Responsibilities:

• Perform in-depth LC-MS based characterization of therapeutic biologic molecules and their post-translational modifications.
• Conduct biophysical and biochemical characterization of biologic drug candidates, as needed.
• Execute experimental protocols, collect results, and perform data analysis carefully and independently.
• Maintain excellent documentation of work including electronic lab notebook and protocols.
• Prepare and deliver concise scientific presentations of experimental results.
• Oversee maintenance of key laboratory equipment and routine laboratory operations.
• Build strong relationships with other team members and across groups.
• Understand and adhere to corporate standards regarding code of conduct, safety, and documentation compliance.

Qualifications:

• BS or MS in Biochemistry, Biology, Chemistry (or equivalent, e.g., Chemical Engineering, Pharmaceutical Sciences) with 5+ (BS) or 2+ years (MS), or Ph.D. with 0+ years of biopharmaceutical industry experience.
• Hands-on experience with protein mass-spectrometry (subunit analysis, peptide mapping, disulfide mapping) and data processing is required.
• Experience with biochemical and biophysical characterization of biologic proteins would be desirable.
• Experience with liquid handling robots and their programming would be highly beneficial.
• Demonstrated track record of independent thinking, creativity, and scientific accomplishment.
• Highly responsible and self-motivated. Skills to plan and conduct experiments with high quality and timely deliverables.
• Able to perform data analysis using MS Excel & GraphPad.
• Team player with excellent collaboration and communication skills.